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He was born in Altoona, Pennsylvania to Bernie and Peggy (Hallinan) Joyce, the third generation of the Joyce family to be born and raised in Altoona. A 1975 graduate of Bishop Guilfoyle High School, John attended Penn State Altoona for two years and then continued his undergraduate education at Penn State University Park. He graduated with honors with a degree in biology in 1979. John continued his education at Temple University, receiving his M.D. in 1983. Subsequently, he completed a 3-year internal medicine residency as a Johns Hopkins fellow in Baltimore, Maryland. He then completed a residency in Dermatology at Johns Hopkins, finishing as chief resident. Dr. Joyce is a fellow in the American College of Physicians and the American Academy of Dermatology.